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SAN FRANCISCO, Jan. 1 (Xinhua) -- Jennifer Dionne, associate professor of materials science and engineering at Stanford University, has teamed up with Miriam B. Goodman, a professor of molecular and cellular physiology, to feed nanoparticles to millimeter-long worms.
When struck by a near-infrared laser, the particular nanoparticles glow and change color depending on the pressure around them, giving off real-time information about the forces they're undergoing while they're still inside the barely visible worms, known as Caenorhabditis elegans, according to a Stanford University news release on Sunday.
The ultimate goal of the work by the interdisciplinary partnership is to detect force in human cells, because as in humans, digestion in worms involves mechanical gnashing and shoving that can provide insight into how these nanoparticles register cellular force.
"Altered cellular-level forces underlie many disorders, including heart disease and cancer," said Dionne. "This would be a nanoscale readout that you could use in vitro or in vivo to detect disease at a very early stage."