It did so by blocking the body's receptors for endocannibinoids -- messenger chemicals that play a role in metabolism and energy use as well as in mood, pain perception and satiety. While many of the body's cannibinoid receptors reside in the brain (hence their role in mood) Womens Qadree Ollison Jersey , some also operate in such organs as the liver and in fat -- which, in the obese, plays a powerful role in sending signals that say, in effect, "feed me."
But since scientists suspect that blocking cannabinoid receptors in the brain may wreak havoc on mood Womens John Cominsky Jersey , the key here was to find a way to block cannabinoid receptors throughout the body but not in the brain's cortical regions.
This is what they did, modifying a cannabinoid blocker called SLV319 so that it could not penetrate the blood-brain barrier.
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